The US Food and Drug Administration has approved the powerful wakefulness-promoting medication Modalert 200mg USA to treat excessive daytime sleepiness in people with narcolepsy, shift work disorder, and obstructive sleep apnea/hypopnea syndrome. It is a CNS stimulant that functions as a reuptake inhibitor of the dopamine transporter (DAT), and its wakefulness-promoting effects are caused by an increase in brain dopamine levels. Additionally, Modafinil causes the hypothalamus's orexin neurons to release a range of peptides that both promote awake and prevent sleep.

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